Dedicate uplinks for DSF, modify current cluster?

I have a test 3-node Nutanix cluster. Just starting to learn. They are NX G9s. Each node has 4x25GB ports, but during installation only 2 were configured. Is it possible, or even best practice, to islolate the storage traffic from the VM traffic? Ie, maybe configure the unused 2 ports as another vSwtich and run the distributed fabric over that? If so, even possible to do this after install? Apologies for any misunderstandings.