Cluster Setup With 3 Different NUCs | Nutanix Community
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Planning for moving from VMware to Nutanix CE. 

I have 3 NUC,
Skull Canyon 
Hades Canyon . 
Wall Street Canyon


Planning to populate 2x1TB ssd to each of the NUC. 

Before dumping money in to populate my NUCs with SSDs, i would like to check if there are any potential problem to setup a 3 host cluster with 3 different CPU architecture?

It will work, It is for a lab so no worries. Although you will have NIC dirver issues. So install the older version, with the nic driver rpm and you are good to go.