The Nutanix cluster in Vcenter must be configured according to Nutanix best practices.
A quick checklist for the recommended settings review is as follows:
vSphere HA Settings
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Enable host monitoring
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Enable admission control and use the percentage-based policy with a value based on the number of nodes in the cluster.
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Set the VM Restart Priority of all Controller VMs to Disabled.
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Set the Host Isolation Response of the cluster to Power Off.
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Set the Host Isolation Response of all Controller VMs to Disabled.
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Set the VM Monitoring for all Controller VMs to Disabled.
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Enable Datastore Heartbeating by clicking Select only from my preferred datastores and choosing the Nutanix NFS datastore. If the cluster has only one datastore, add an advanced option named das.ignoreInsufficientHbDatastore with Value of true.
vSphere DRS Settings
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Set the Automation Level on all Controller VMs to Disabled.
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Leave power management disabled (set to Off).
Other Cluster Settings
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Store VM swapfiles in the same directory as the virtual machine.
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Enable EVC in the cluster.
The detailed configuration guide can be found at: