Regardless of the reason to destroy the cluster whether it is to relocate and reuse an existing kit or switch to a different hypervisor, to build something new often means to destroy something that already exists and Nutanix has a process for it.
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Migrate all user VMs off the cluster.
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Reclaim licenses. Ensure there are no errors displayed.
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Stop the cluster.
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Destroy the cluster.
Not too bad, right?
Some things to keep in mind is that cluster destruction does not affect either:
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IPMI configuration. Which is convenient if you wish to re-use the settings in the new environment.
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Installed hypervisor. Nodes would have to be re-imaged should a different hypervisor be required.
Migrate all workloads off the cluser prior to executing the cluster destroy. Cluster destroy clears all metadata and data on the storage.
Useful links:
KB-3716 Reclaiming Cluster License
Acropolis Advanced Administration Guide: Destroying a Cluster