Let say for example you're running ESXi 6.5 U1 and want to upgrade to the latest ESXi version but confused whether the current hardware and AOS will support the latest ESXi version.

Nutanix gives you a feature to identify the compatability of different Hypervisors with NX environment easily using the Compatibility Matrix.

You just need to visit the compatibility matrix page, filter by using your hardware and AOS and you will see the hypervisors which are supported.

Still confused before the hypervisor upgrade?

Refer the following document regarding general guidelines before the hypervisor upgrade.
Hypervisor-upgrade-guidelines