If your hypervisor is ESXi you know how vCenter manages all the Vms in the vmware data center. You can either use vCenter for Vm management or Prism to control to do most of the same.
This stated long ago after AOS 5.0 was released. Most core VM management functions like creating, cloning, updating and deleting VMs, and attaching/deleting disks and NICs as well as power operations alongside console access and guest tool management
But for most of the above you will need to register the prism with vCenter. There are rules and guidelines and requirements and limitations that you need to be aware of. You can find out about these and how to register/unregister prism element with vCenter by reviewing:
One thing to notice is that the network traffic between the Prims and vCenter will be much higher than usual when prism is not register with vcenter.
Ask any questions about it if you have concerns about the above.