Paul, since this is enabled by default in Cisco ACI, my recommendation would be to leave it enabled.

My other advice would be to defer to Cisco and their guidance about this feature since they would be the authoritative source. If you need help getting in touch with your local Cisco team we can help there to find the definitive answer.

With it enabled, be careful if you have what would be considered rouge IP/end points. Usually related to F5 load balancers. You will experience flapping and disconnects.