The Microsoft Exchange Solution references for Nutanix are all based on iSCSI LUNs mapped into the Exchange VMs, and the Nutanix whitepaper on Exchange seems to recommend the same thing.
For its part, Rubrik says it cannot use VSS backups with iSCSI LUNs so the backups will not be crash or application consistent.
If anyone has any experience with this kind of setup we would love to hear how it worked out for you.
Best answer by MarkNijmeijer
This is something we are working with Rubrik on. One of the upcoming releases will have the AOS snapshot capabilities for the iSCSI VGs for backup vendors like Rubrik to integrate with, so then they can offer end-to-end protection for such Exchange setups.
-- Mark Nijmeijer
Nutanix PM for Data Protection